This Health Research Program opportunity is with Dr. Arthur Gunzl, Department of Genetics & Genome Sciences.
Project Description: Our research is on gene expression factors and mechanisms in the lethal human parasite and unicellular eukaryote Trypanosoma brucei (we work with a strain that is not infectious for humans). Trypanosomes use an obligatory trans splicing process that is not present in human cells to mature all pre-mRNAs. Trans splicing is carried out by the spliceosome and we are interested in discovering parasite-specific proteins that are important to this process. For example, we have characterized a unique kinase whose activity is indispensable for trans splicing. This project is to proteomically characterize the trypanosome U4/U5.U6 tri-snRNP and analyze all co-purified proteins and small nuclear RNAs.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-14
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU24-14: Research Opportunity with Dr. Arthur Gunzl
This Health Research Program opportunity is with Dr. Arthur Gunzl, Department of Genetics & Genome Sciences.
Project Description: Our research is on gene expression factors and mechanisms in the lethal human parasite and unicellular eukaryote Trypanosoma brucei (we work with a strain that is not infectious for humans). Trypanosomes use an obligatory trans splicing process that is not present in human cells to mature all pre-mRNAs. Trans splicing is carried out by the spliceosome and we are interested in discovering parasite-specific proteins that are important to this process. For example, we have characterized a unique kinase whose activity is indispensable for trans splicing. This project is to proteomically characterize the trypanosome U4/U5.U6 tri-snRNP and analyze all co-purified proteins and small nuclear RNAs.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-14
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.