This Health Research Program opportunity is with Dr. Srdjan Antic, Department of Neuroscience.
Project Description: This is a basic science research project aimed at understanding cellular determinants of Alzheimer’s disease (AD). We use an animal model of AD -- mice carrying specific genes, which trigger development of amyloid plaques in the cerebral cortex. By the means of brain slice technology, electrophysiology (synaptic stimulation), and optical imaging (calcium and voltage imaging) we seek to determine if synaptic transmission in disease-free animals (Control) is any different from that occurring in the AD model animals developing amyloid plaques. The student will learn software for analysis of the optical imaging records (physiological), organization and presentation of measurements, some basic histology techniques for detecting plaques in saved brain sections, and if interested, the student may perform optical imaging of synaptically evoked depolarizations in brain slices working together with a postdoc.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-2
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU24-2: Research Opportunity with Dr. Srdjan Antic
This Health Research Program opportunity is with Dr. Srdjan Antic, Department of Neuroscience.
Project Description: This is a basic science research project aimed at understanding cellular determinants of Alzheimer’s disease (AD). We use an animal model of AD -- mice carrying specific genes, which trigger development of amyloid plaques in the cerebral cortex. By the means of brain slice technology, electrophysiology (synaptic stimulation), and optical imaging (calcium and voltage imaging) we seek to determine if synaptic transmission in disease-free animals (Control) is any different from that occurring in the AD model animals developing amyloid plaques. The student will learn software for analysis of the optical imaging records (physiological), organization and presentation of measurements, some basic histology techniques for detecting plaques in saved brain sections, and if interested, the student may perform optical imaging of synaptically evoked depolarizations in brain slices working together with a postdoc.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-2
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.