This Health Research Program opportunity is with Dr. Rajkumar Verma, Department of Neurosciences.
Project Description: Following a stroke, a surge of ATP is released from compromised brain cells. This surge, in turn, triggers a cascade of events, including the activation of neurons and microglial purinergic receptor P2X4 (P2X4R). This activation facilitates rapid excitatory neurotransmission through the influx of cations. However, excessive activation of P2X4R can lead to the release of several pro-inflammatory cytokines during the initial stages of ischemic injury. Interestingly, the effects of acute activation stand in contrast to those observed with chronic inhibition or the absence of this receptor. In fact, prolonged inhibition or the lack of P2X4R might hinder the process of stroke recovery. Thus, acknowledging the dual role of P2X4R in different phases of ischemic injury, we are currently engaged in a systematic exploration of its potential as a therapeutic target for enhancing post-stroke recovery. In essence, our research endeavors revolve around deciphering the intricate role of P2X4R, recognizing its potential as a double-edged sword in stroke-induced processes. Through a comprehensive understanding of its temporal dynamics, we aim to pave the way for innovative therapeutic interventions that can tip the balance in favor of improved recovery outcomes.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-37
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU24-37: Research Opportunity with Dr. Rajkumar Verma
This Health Research Program opportunity is with Dr. Rajkumar Verma, Department of Neurosciences.
Project Description: Following a stroke, a surge of ATP is released from compromised brain cells. This surge, in turn, triggers a cascade of events, including the activation of neurons and microglial purinergic receptor P2X4 (P2X4R). This activation facilitates rapid excitatory neurotransmission through the influx of cations. However, excessive activation of P2X4R can lead to the release of several pro-inflammatory cytokines during the initial stages of ischemic injury. Interestingly, the effects of acute activation stand in contrast to those observed with chronic inhibition or the absence of this receptor. In fact, prolonged inhibition or the lack of P2X4R might hinder the process of stroke recovery. Thus, acknowledging the dual role of P2X4R in different phases of ischemic injury, we are currently engaged in a systematic exploration of its potential as a therapeutic target for enhancing post-stroke recovery. In essence, our research endeavors revolve around deciphering the intricate role of P2X4R, recognizing its potential as a double-edged sword in stroke-induced processes. Through a comprehensive understanding of its temporal dynamics, we aim to pave the way for innovative therapeutic interventions that can tip the balance in favor of improved recovery outcomes.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su24-37
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.