This Health Research Program opportunity is with Dr. Mallika Ghosh, Center for Vascular Biology.
Project Description: Cell-cell fusion is a highly specialized process mediated by fusion regulatory proteins involved in a variety of diverse
cellular functions. CD13, a transmembrane protein that we study in my lab, controls many events including adhesion,
migration, membrane organization, and endocytosis which are critical in cell-cell fusion. We hypothesize that CD13
is a negative regulator of cell-cell fusion during osteoclastogenesis and macrophage giant cell formation, and thus is
a novel target for therapeutic intervention in pathological conditions mediated by defects in cell-cell fusion such as
osteoporosis and failure of medical implants such as hernia mesh, glucose sensors, stents, and many medical devices.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-10
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU25-10: Research Opportunity with Dr. Mallika Ghosh
This Health Research Program opportunity is with Dr. Mallika Ghosh, Center for Vascular Biology.
Project Description: Cell-cell fusion is a highly specialized process mediated by fusion regulatory proteins involved in a variety of diverse
cellular functions. CD13, a transmembrane protein that we study in my lab, controls many events including adhesion,
migration, membrane organization, and endocytosis which are critical in cell-cell fusion. We hypothesize that CD13
is a negative regulator of cell-cell fusion during osteoclastogenesis and macrophage giant cell formation, and thus is
a novel target for therapeutic intervention in pathological conditions mediated by defects in cell-cell fusion such as
osteoporosis and failure of medical implants such as hernia mesh, glucose sensors, stents, and many medical devices.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-10
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.