This Health Research Program opportunity is with Dr. Andres Grosmark, Neuroscience Department.
Project Description: The cognitive maps that we use to navigate the world around serve as a fundamental stage in which we organize our day-to-day memories (what happened where) and the ability to generate and use these maps is one of the first cognitive capacities to decline in a number of psychiatric diseases including Alzheimer's disease (AD). My lab studies the formation and long-term evolution of spatial cognitive maps in mice traversing through 3D virtual reality environments using custom made 3d headsets, while we either track the real-time activity of thousands of neurons with two-photon imaging or manipulate neural activity using optogenetic methods. This combination of modern tools allow us to get a unique view of memory that is both detailed - looking at the activity of thousands individual neurons, and broad - tracking these neurons over many days and relating their activity to behavior in both healthy and AD mice. The insights gained from these studies will help us better understand the foundations of how our memories both define and are defined by the world around us, and how these processes can go awry in psychiatric diseases such as AD.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-11
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU25-11: Research Opportunity with Dr. Andres Grosmark
This Health Research Program opportunity is with Dr. Andres Grosmark, Neuroscience Department.
Project Description: The cognitive maps that we use to navigate the world around serve as a fundamental stage in which we organize our day-to-day memories (what happened where) and the ability to generate and use these maps is one of the first cognitive capacities to decline in a number of psychiatric diseases including Alzheimer's disease (AD). My lab studies the formation and long-term evolution of spatial cognitive maps in mice traversing through 3D virtual reality environments using custom made 3d headsets, while we either track the real-time activity of thousands of neurons with two-photon imaging or manipulate neural activity using optogenetic methods. This combination of modern tools allow us to get a unique view of memory that is both detailed - looking at the activity of thousands individual neurons, and broad - tracking these neurons over many days and relating their activity to behavior in both healthy and AD mice. The insights gained from these studies will help us better understand the foundations of how our memories both define and are defined by the world around us, and how these processes can go awry in psychiatric diseases such as AD.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-11
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.