This Health Research Program opportunity is with Dr. Guangfu Li, Surgery.
Project Description: A high fat and high sugar diet (HFS), a typical Western-type diet (WD), is now recognized as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). Mounting evidence indicates that the interaction between HFS and gut microbiota generates a spectrum of dietary and microbial components and outcome metabolites that can induce inappropriate hepatic immune activation, suggesting a key role of the diet/gut/liver/immune axis in NASH. However, the mechanisms underlying HFS-induced hepatic pathologic reactions are poorly understood. Furthermore, very little is known about the specific microbes and metabolites that regulate intrahepatic immunity. We propose to address these major knowledge gaps by identifying NASH-associated microbes and metabolites and dissecting the underlying cellular and molecular mechanisms.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-17
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU25-17: Research Opportunity with Dr. Guangfu Li
This Health Research Program opportunity is with Dr. Guangfu Li, Surgery.
Project Description: A high fat and high sugar diet (HFS), a typical Western-type diet (WD), is now recognized as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). Mounting evidence indicates that the interaction between HFS and gut microbiota generates a spectrum of dietary and microbial components and outcome metabolites that can induce inappropriate hepatic immune activation, suggesting a key role of the diet/gut/liver/immune axis in NASH. However, the mechanisms underlying HFS-induced hepatic pathologic reactions are poorly understood. Furthermore, very little is known about the specific microbes and metabolites that regulate intrahepatic immunity. We propose to address these major knowledge gaps by identifying NASH-associated microbes and metabolites and dissecting the underlying cellular and molecular mechanisms.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-17
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.