This Health Research Program opportunity is with Dr. Sebnem Tuncdemir, Neuroscience.
Project Description: Discrimination of different contexts composed of distinct constellations of multisensory cues is a hallmark of both episodic memory and spatial navigation, two functions ascribed to the mammalian hippocampus. On the other hand, impairments in contextual discrimination of non-traumatic memories is a hallmark of many stress and trauma disorders, including posttraumatic stress disorder (PTSD); yet, the neural mechanisms by which traumatic contexts are generalized remain unclear. This project will examine whether manipulating the activity of inputs to the hippocampal dentate gyrus can rescue context discrimination deficits in a PTSD model in mice. The student will perform intraperitoneal injections, behavioral induction and testing of contextual fear learning followed by histological examinations and data analysis.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-32
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU25-32: Research Opportunity with Dr. Sebnem Tuncdemir
This Health Research Program opportunity is with Dr. Sebnem Tuncdemir, Neuroscience.
Project Description: Discrimination of different contexts composed of distinct constellations of multisensory cues is a hallmark of both episodic memory and spatial navigation, two functions ascribed to the mammalian hippocampus. On the other hand, impairments in contextual discrimination of non-traumatic memories is a hallmark of many stress and trauma disorders, including posttraumatic stress disorder (PTSD); yet, the neural mechanisms by which traumatic contexts are generalized remain unclear. This project will examine whether manipulating the activity of inputs to the hippocampal dentate gyrus can rescue context discrimination deficits in a PTSD model in mice. The student will perform intraperitoneal injections, behavioral induction and testing of contextual fear learning followed by histological examinations and data analysis.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-32
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.