This Health Research Program opportunity is with Dr. Caroline Dealy, Orthodontics, Orthopedic Surgery, Biomedical Engineering, Cell Biology.
Project Description: The meniscus is a C-shaped fibrocartilage cushion that stabilizes and protects the knee joint. Tears to the meniscus are common and often heal poorly, even when surgically repaired. This project is a collaboration with Orthopedic surgeons who are providing tissue from patients with meniscal tears. The project will compare the transcriptome of meniscal tears that heal poorly to those that heal well. The long term goal is to identify genes that correlate with better healing outcomes, which might offer potential for clinical use as meniscal pro-healing factors. Experiments this summer will include preparation of meniscal cell isolates and analysis of RNA transcriptomal data using bioinformatics software. Additionally, there is opportunity to carry out validation studies in meniscal tissue sections. All IRB approvals for this project are already in place; as are University-approved safety protocols for handing human tissue.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-6
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU25-6: Research Opportunity with Dr. Caroline Dealy
This Health Research Program opportunity is with Dr. Caroline Dealy, Orthodontics, Orthopedic Surgery, Biomedical Engineering, Cell Biology.
Project Description: The meniscus is a C-shaped fibrocartilage cushion that stabilizes and protects the knee joint. Tears to the meniscus are common and often heal poorly, even when surgically repaired. This project is a collaboration with Orthopedic surgeons who are providing tissue from patients with meniscal tears. The project will compare the transcriptome of meniscal tears that heal poorly to those that heal well. The long term goal is to identify genes that correlate with better healing outcomes, which might offer potential for clinical use as meniscal pro-healing factors. Experiments this summer will include preparation of meniscal cell isolates and analysis of RNA transcriptomal data using bioinformatics software. Additionally, there is opportunity to carry out validation studies in meniscal tissue sections. All IRB approvals for this project are already in place; as are University-approved safety protocols for handing human tissue.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrpsu25-6
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.