This Health Research Program opportunity is with Dr. Arthur Gunzl, Department of Genetics and Genome Sciences.
Project Description: We work on a lethal parasite called Trypanosoma brucei which causes disease in humans and animals in sub-Saharan Africa (we work with a strain that is not infectious to humans). We are interested in the unusual gene expression mode of this parasite and currently focus on the cyclin-dependent kinase CRK9 whose activity is essential for pre-mRNA splicing in the parasite. More specifically, the kinase activity is required for activation of the spliceosome by phosphorylating its substrate, the splicing protein SF3B1, just prior to activation. We hypothesize that a special "RS" domain in the cyclin is required for recognizing SF3B1 within the precatalytic spliceosome. This project is to test this hypothesis.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-15
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU26-15: Research Opportunity with Dr. Arthur Gunzl
This Health Research Program opportunity is with Dr. Arthur Gunzl, Department of Genetics and Genome Sciences.
Project Description: We work on a lethal parasite called Trypanosoma brucei which causes disease in humans and animals in sub-Saharan Africa (we work with a strain that is not infectious to humans). We are interested in the unusual gene expression mode of this parasite and currently focus on the cyclin-dependent kinase CRK9 whose activity is essential for pre-mRNA splicing in the parasite. More specifically, the kinase activity is required for activation of the spliceosome by phosphorylating its substrate, the splicing protein SF3B1, just prior to activation. We hypothesize that a special "RS" domain in the cyclin is required for recognizing SF3B1 within the precatalytic spliceosome. This project is to test this hypothesis.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-15
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.