This Health Research Program opportunity is with Dr. Srdjan Antic, department of Neuroscience.
Project Description:Using acute brain slice preparations, electrophysiological approaches (synaptic stimulation, whole-cell patch-clamp recordings), and optical imaging techniques (calcium imaging, voltage imaging), we aim to determine whether synaptic transmission in disease-free control animals differs from that observed in Alzheimer’s disease (AD) model mice that develop amyloid plaques characteristic of the disorder. - - Students involved in this project will gain experience with software for quantitative analysis of physiological optical imaging data, organization and presentation of experimental measurements, and basic histological techniques for detecting amyloid plaques in archived brain sections. - - Students who are interested will also have the opportunity to perform optical imaging of synaptically evoked depolarizations in brain slices in close collaboration with a postdoctoral researcher. Optical imaging experiments (calcium and voltage imaging) will frequently be complemented by patch-electrode recordings, providing an excellent opportunity for students to learn whole-cell patch-clamp techniques in acute (living) brain slices prepared from mouse neocortex or striatum.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-3
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU26-3: Research Opportunity with Dr. Srdjan Antic
This Health Research Program opportunity is with Dr. Srdjan Antic, department of Neuroscience.
Project Description:Using acute brain slice preparations, electrophysiological approaches (synaptic stimulation, whole-cell patch-clamp recordings), and optical imaging techniques (calcium imaging, voltage imaging), we aim to determine whether synaptic transmission in disease-free control animals differs from that observed in Alzheimer’s disease (AD) model mice that develop amyloid plaques characteristic of the disorder. - - Students involved in this project will gain experience with software for quantitative analysis of physiological optical imaging data, organization and presentation of experimental measurements, and basic histological techniques for detecting amyloid plaques in archived brain sections. - - Students who are interested will also have the opportunity to perform optical imaging of synaptically evoked depolarizations in brain slices in close collaboration with a postdoctoral researcher. Optical imaging experiments (calcium and voltage imaging) will frequently be complemented by patch-electrode recordings, providing an excellent opportunity for students to learn whole-cell patch-clamp techniques in acute (living) brain slices prepared from mouse neocortex or striatum.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-3
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.