This Health Research Program opportunity is with Dr. Henry Smilowitz, Department of Cell Biology.
Project Description: The overall focus of our lab has been experimental cancer therapeutics. Current Projects: 1. Our lab has been collaborating with a small biotech company that has developed novel heavy atom nanoparticles (NPs). We have recently shown that the well tolerated BaTiO3 NPs significantly enhance megavoltage radiation therapy (RT) of both tumor cells growing in vitro and in vivo tumors growing subcutaneously on the thighs of mice after intravenous injection 24 hrs prior to RT. Going forward we want to improve NP-mediated radio-enhancement by a. increasing the specific NP loading of tumors and altering their distribution in the tumors by using a variety of techniques including specific targeting, pre-irradiation, hyperthermia, ultrasound, combining intratumoral and intravenous routes of administration, b. by combination therapies including radiosensitization, immunotherapy, chemotherapy, c. Comparing proton and photon irradiation.
2. Our lab is collaborating with a laboratory at UCONN Storrs on the use of a novel NP for therapeutic RNA delivery to tumors. An initial publication on this has recently appeared in ACS Nano.
Please refer to Dr. Smilowitz's Cell Biology Blurb for research interests and publications since 2000.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-34
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU26-34: Research Opportunity with Dr. Henry Smilowitz
This Health Research Program opportunity is with Dr. Henry Smilowitz, Department of Cell Biology.
Project Description: The overall focus of our lab has been experimental cancer therapeutics. Current Projects: 1. Our lab has been collaborating with a small biotech company that has developed novel heavy atom nanoparticles (NPs). We have recently shown that the well tolerated BaTiO3 NPs significantly enhance megavoltage radiation therapy (RT) of both tumor cells growing in vitro and in vivo tumors growing subcutaneously on the thighs of mice after intravenous injection 24 hrs prior to RT. Going forward we want to improve NP-mediated radio-enhancement by a. increasing the specific NP loading of tumors and altering their distribution in the tumors by using a variety of techniques including specific targeting, pre-irradiation, hyperthermia, ultrasound, combining intratumoral and intravenous routes of administration, b. by combination therapies including radiosensitization, immunotherapy, chemotherapy, c. Comparing proton and photon irradiation.
2. Our lab is collaborating with a laboratory at UCONN Storrs on the use of a novel NP for therapeutic RNA delivery to tumors. An initial publication on this has recently appeared in ACS Nano.
Please refer to Dr. Smilowitz's Cell Biology Blurb for research interests and publications since 2000.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-34
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.