This Health Research Program opportunity is with Dr. Dong Zhou, Department of Medicine.
Project Description: This summer project will investigate how the immune cell–expressed G-protein-coupled receptor Smoothened (Smo) influences the outcome of acute kidney injury (AKI). Our published work has shown that deletion of Smo in fibroblasts attenuates AKI severity by creating a more favorable microenvironment. However, despite the central role of immune cells in shaping the AKI microenvironment, very few studies have examined the specific function of immune cell–derived Smo in renal injury and repair. To address this critical gap, this project aims to elucidate the mechanisms by which immune cell–expressed Smo regulates AKI onset, progression, and resolution. The student will gain hands-on experience with in vivo, in vitro, and ex vivo experimental approaches, and will develop foundational bioinformatic skills to analyze proteomic datasets generated during the study. Through this integrative research experience, the student will develop a comprehensive understanding of immune-tubule interactions in AKI and the molecular pathways controlled by Smo signaling in kidney injury.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-43
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU26-43: Research Opportunity with Dr. Dong Zhou
This Health Research Program opportunity is with Dr. Dong Zhou, Department of Medicine.
Project Description: This summer project will investigate how the immune cell–expressed G-protein-coupled receptor Smoothened (Smo) influences the outcome of acute kidney injury (AKI). Our published work has shown that deletion of Smo in fibroblasts attenuates AKI severity by creating a more favorable microenvironment. However, despite the central role of immune cells in shaping the AKI microenvironment, very few studies have examined the specific function of immune cell–derived Smo in renal injury and repair. To address this critical gap, this project aims to elucidate the mechanisms by which immune cell–expressed Smo regulates AKI onset, progression, and resolution. The student will gain hands-on experience with in vivo, in vitro, and ex vivo experimental approaches, and will develop foundational bioinformatic skills to analyze proteomic datasets generated during the study. Through this integrative research experience, the student will develop a comprehensive understanding of immune-tubule interactions in AKI and the molecular pathways controlled by Smo signaling in kidney injury.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-43
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.