This Health Research Program opportunity is with Dr. Caroline Dealy, Department of Orthodontics, Orthopedic Surgery, Biomedical Engineering, Cell Biology.
Project Description: Rheumatoid Arthritis and Spondylosing Ankylosis are auto-immune diseases that affect the small joints of the hands and feet (RA) and the intervertebral "joints" of the spine (AS), causing severe pain and disability for patients. The mechanisms that underlie these diseases are poorly understood, hampering development of effective treatments. This summer project will characterize joint damage in paws and spines harvested from an unusual mouse model of dual RA/AS disease. Characterization will focus on histological examination of the paws and spines including expression of protein/gene markers of cellular differentiation or behavior (stem cells, apoptosis, proliferation, etc.), and micro-CT (computer tomography) scanning for features like bone loss or bone fusions. As half of the mice will have received a novel test treatment; this analysis will also test the hypothesis that the treatment blocks joint destruction.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-7
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.
HRP SU26-7: Research Opportunity with Dr. Caroline Dealy
This Health Research Program opportunity is with Dr. Caroline Dealy, Department of Orthodontics, Orthopedic Surgery, Biomedical Engineering, Cell Biology.
Project Description: Rheumatoid Arthritis and Spondylosing Ankylosis are auto-immune diseases that affect the small joints of the hands and feet (RA) and the intervertebral "joints" of the spine (AS), causing severe pain and disability for patients. The mechanisms that underlie these diseases are poorly understood, hampering development of effective treatments. This summer project will characterize joint damage in paws and spines harvested from an unusual mouse model of dual RA/AS disease. Characterization will focus on histological examination of the paws and spines including expression of protein/gene markers of cellular differentiation or behavior (stem cells, apoptosis, proliferation, etc.), and micro-CT (computer tomography) scanning for features like bone loss or bone fusions. As half of the mice will have received a novel test treatment; this analysis will also test the hypothesis that the treatment blocks joint destruction.
For full details about this Health Research Program opportunity, visit https://ugradresearch.uconn.edu/hrp/su26-7
For full details about the Health Research Program, visit ugradresearch.uconn.edu/hrp/
Submissions to this program are made via a third-party software application, SurveyMonkey Apply. The terms of use and privacy statements for this software apply to your use of it and to the information you provide in your application. Before proceeding with your submission, please review their terms and privacy statements linked below.